|本期目錄/Table of Contents|

[1]程廣超,楊萍,赫晨,等.社會隔離對雌性小鼠動情周期及中樞ERα和TH免疫活性表達的影響[J].江蘇農業科學,2019,47(14):197-201.
 Cheng Guangchao,et al.Impacts of social isolation on estrous cycle and immunoreactivity of ERα and TH in female mice[J].,2019,47(14):197-201.
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社會隔離對雌性小鼠動情周期及中樞ERα
和TH免疫活性表達的影響
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《江蘇農業科學》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期數:
2019年第14期
頁碼:
197-201
欄目:
畜牧獸醫與水産蠶桑
出版日期:
2019-08-10

文章信息/Info

Title:
Impacts of social isolation on estrous cycle and immunoreactivity of ERα and TH in female mice
作者:
程廣超12 楊萍1 赫晨1 楊斌1 王建禮12
1.北方民族大學生物科學與工程學院,甯夏銀川 750021; 2.國家民委生態建模與應用重點實驗室,甯夏銀川 750021
Author(s):
Cheng Guangchaoet al
關鍵詞:
隔離雌性小鼠動情周期雌激素多巴胺免疫活性表達
Keywords:
-
分類號:
Q492
DOI:
-
文獻標志碼:
A
摘要:
雌激素受體(ERα)和多巴胺(DA)可參與雌性動物動情周期調節,故本研究通過酪氨酸羟化酶(TH)標記DA神經元,探討了社會隔離對雌性動情周期及ERα和DA的影響。成年雌性ICR小鼠社會隔離10 d後,檢測其動情周期變化及動情期和動情間期中樞ERα-IR和TH-IR神經元表達。結果發現,社會隔離延長了雌鼠的動情前期和動情期(P<0.05),但對動情後期和動情間期沒有影響;社會隔離和動情周期均會顯著影響終紋床核(BNST)、內側視前區(MPOA)和下丘腦弓狀核(AR)的ERα-IR神經元表達(P<0.05),並對AR的ERα-IR表達和中腦腹側被蓋區(VTA)的TH-IR神經元表達有交互影響(P<0.05),表現爲社會隔離減少動情期AR的ERα-IR表達(P<0.05),增加動情期和動情間期TH-IR表達(P<0.05),且對動情期的影響更明顯。提示社會隔離會幹擾雌鼠的動情周期,ERα和DA在特定腦區的變化對此具有重要調制作用。
Abstract:
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備注/Memo

備注/Memo:
收稿日期:2018-03-30
基金項目:國家自然科學基金(編號:31460565);甯夏優秀人才支持計劃;甯夏回族自治區大學生創新計劃(編號:QJCX-2017-033)。
作者簡介:程廣超(1990—),男,內蒙古赤峰人,碩士,主要從事行爲生理學研究。E-mail:761408199@qq.com。
通信作者:王建禮,博士,教授,主要從事行爲生理學研究。E-mail:wang_jianli@163.com。
更新日期/Last Update: 2019-07-20